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Promethazine and codeine should be applied during pregnancy provided that the probable advantage justifies the prospective danger towards the fetus.
Existence-threatening respiratory depression and Loss of life have transpired in kids who been given codeine. Codeine is subject matter to variability in metabolism based mostly upon CYP2D6 genotype (described below), which can lead to an increased exposure on the Lively metabolite morphine. Dependent upon article-internet marketing stories, little ones younger than twelve several years previous seem like much more at risk of the respiratory depressant consequences of codeine, especially if you will find chance things for respiratory despair.
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The narcotic antagonist, naloxone hydrochloride, may be administered when major respiratory melancholy takes place with promethazine and codeine; any depressant outcomes of promethazine usually are not reversed with naloxone. Diazepam might be used to regulate convulsions. Keep away from analeptics, which may lead to convulsions. Acidosis and electrolyte losses must be corrected. A rise in temperature or pulmonary difficulties may possibly sign the need for establishment of antibiotic therapy.
Just before taking this medication, notify your medical professional or pharmacist If you're allergic to any of its elements; or to opioid ache relievers (which include morphine); or In case you have another allergic reactions.
The mix of promethazine hydrochloride and codeine check here phosphate is contraindicated in pediatric sufferers less than six a long time of age, simply because The mix might trigger deadly respiratory despair On this age inhabitants (see WARNINGS – Box Warning and Use In Pediatric Individuals).
Long-phrase usage of opioid medication may perhaps impact fertility (power to have kids) in Gentlemen or Gals. It is not known whether or not opioid effects on fertility are long-lasting.
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It really is soluble in h2o and freely soluble in Alcoholic website beverages. It's got a molecular weight of 320.88, a molecular system of C17H20N2S•HCI, and the subsequent structural formulation:
Certain reports to test the motion with the drug on parturition, lactation, and progress from the animal neonate weren't done, but a common preliminary research in rats indicated no effect on these parameters.
Promethazine with Codeine Oral Option is contraindicated for read more all kids youthful than 12 yrs of age [see Contraindications ( four) ]. Promethazine with Codeine Oral Alternative is contraindicated for publish-operative management in pediatric individuals more youthful than eighteen decades of age next tonsillectomy and/or adenoidectomy [see Contraindications ( 4) ]. Keep away from the use of Promethazine with Codeine Oral Remedy in adolescents twelve to eighteen many years of age who have other risk elements that will boost their sensitivity towards the respiratory depressant consequences of codeine Except the benefits outweigh the threats.
Important: When There may be A selection of pricing, people need to Ordinarily expect to pay for the cheaper price. However, because of stock shortages as well as other mysterious variables we cannot deliver any assurance. Codeine/phenylephrine/promethazine Coupons, Copay Cards and Rebates